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Project: Prediction of mortality from Gram negative pneumonia

Investigators: Mark R. Hemmila, Aladdein Mattar at University of Michigan. Created at: 2007-09-21 10:45. Last updated at: 2007-09-21 10:45.

Grant support: NIH K08, ACS/AAST.


We are trying to study the pathogenesis of Gram negative pneumonia. Previously we have found that lipopolysaccharide binding protein knockout mice have increased mortality compared to controls. We would like to elucidate the mechanisms that are responsible for this difference in survival. Because the mice become sick at different time periods after inoculation with bacteria we are interested in determining simple physiologic or chemical measures that may predict impending mortality. This would aid us in timing the sacrifice of animals for cytokine and tissue sampling.

Status: Approved


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Analyses: Refresh

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